The article we have covered in a previous week, “Hypothalmic inflammation in obesity and metabolic disease” by Alexander Jais and Jens C. Brüning was an article about metabolic inflammation being connected to obesity in many surprising ways. Basically, we know already that obesity is an obstacle for the brain and it’s functioning. However, due to this feature, this is in a way how this correlation works.The topic today is why people should care about this topic and what the people must know, so without further ado let’s get reading!
The article informs us of a typical metabolic homeostasis, and then what happens to it under insulin and leptin resistance. Though, the article specifically focuses mainly on the insulin and leptin resistance aspect. As a result of this connection, we can now at least suspect the connection!
Figure one, pictured above, from the article mentioned above is especially excellent at explaining this where it was needed (excellently timed, or in other words placed well). That piece is a diagram expressing exactly this. The myriad, but consistent colors complements the black parts which either crosses something out, or is a metaphorical old-timey scale. Although, one slight problem could be that it could feel a large bunch overwhelming if you’re not too familiar with the applied terms of figure one in the Neuroscience field. This was an excellent piece to me for it is maximized simplicity because, for clear reasons, that kind of thing strongly helps. The figure may also benefit people uninvolved in Neuroscience as well because figure one uses so much brief, yet descriptive, labeling, and I find that effective myself in general because it’s easy on the eyes to track or logicate.
Now, at this point, one, such as yourself, may wonder why people really should care about all the above information. Well, let’s answer with essential basics to answer ourselves by quickly asking ourselves something simpler first; what really is metabolism? Well, the answer is absolutely nothing short of deeply important. According to Arturo Sánchez López de Nava and Avais Raja, metabolism is known as “the whole sum of reactions that occur throughout the body within each cell and that provide the body with energy.” (Arturo Sánchez López de Nava and Avais Raja 2022).^2 Considering what we know about energy, the ability to do action internally and externally, it’s no shock to pretty much anyone that such a scenario can turn serious fast. Let us put this into perspective with another topic.
In my class, I personally examined the various effects that the person with a penis has in the impact of their child’s birth via their diet. Surprisingly, I learned from the University of Tennessee Institute of Agriculture, even very specific nutritional choices have a direct effect on the child. Using protein as an example, a low amount of protein may cause a higher birth weight while high amounts of protein may lead to glucose intolerance in their child.^3 It is little short of incredible how essential our nutritional choices are, and even more so that we seemingly take little worry to what it does to us.
References:
1) “Hypothalmic inflammation in obesity and metabolic disease” by Alexander Jais and Jens C. Brüning
2)https://www.ncbi.nlm.nih.gov/books/NBK546690
3) https://animalscience.tennessee.edu/wp-content/uploads/sites/7/2022/05/Relevant-Repro-Blog-7_-Paternal-Impacts.pdf
