The endocannibinoids play a vital role in regulation most of your brain and body functions. Without endocannibinoids, we are unable to function properly. Endocannibinoids are a family of molecules synthesized in your body that are found in the nervous system. The most common are anandamide and 2-arachidonoyl glycerol (2-AG). But they are not the only chemicals that can activate signaling in the brain, so can Marijuana.
Tetrahydrocannabinol, or THC, is commonly known for being the active ingredient found in marijuana. (Click to see the structure for those who are organically inclined)
Despite it the bad reputation it gets (not pointing any fingers), THC is useful for more than just getting high. A recent study in the Journal of Clinical Investigation by Salazar et al. shows that “Δ9-tetrahydrocannabinol (THC), the main active component of marijuana, induces human glioma cell death through stimulation of autophagy.” Glioma is a type of cancer specific to the brain and spinal cord. It’s named after the cells that cause it, glial cells. Glial cells are found primarily in the brain, and it is their irrational growth that causes the tumors to form. Basically, the THC gets into the signaling pathway of the cancer cells and tells them to destroy themselves. It is very cool stuff and great for the future of treating deadly cancers.
Another study from Scripps Research Institute, shows that THC is helpful in the treatment of Alzheimer’s Disease. THC stops the formation of protein buildup (amyloid plaque), by inhibiting acetylcholinesterase (AChE). AChE fosters the development of the protein buildup which causes inflammation of neurons in the brain. This is believed to be how Alzheimer’s disease is caused. This research is very interesting, and can lead to studies of novel new treatments.
If you want further information on the recent developments on THC and the endocannibinoid system, the Society for Neuroscience put out a great article on cannabis, and its applications for future research and the treatment of disease, obesity, cancer, pain, and anxiety. (http://www.sfn.org/skins/main/pdf/brainbriefings/BrainBriefings_Dec2007.pdf)
Marijuana, THC, and Medicine
