New Learning in Neurochemistry

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I did not know what to expect when I signed up for this course. I honestly thought it would parallel the neurobiology course some of my classmates had taken last spring. This thought had me worried, as I was very aware of how difficult that class had been. However, I have been pleasantly surprised by neurochemistry. The reason I enjoyed neurochemistry so much is not because of the lighter workload than traditional classrooms or the decreased emphasis on exams (although those were nice benefits), but because it encouraged open discussion and the ability to draw knowledge from many different areas to understand a concept.

The structure of the class created an environment where I wanted to dig deeper and find the answer to the various neurological diseases we read about. We were given a whole week to read a paper, discuss our questions, learn more about topics within the paper, and finally, discuss our thoughts and conclusions with our classmates. This gave us the opportunity to draw connections to what we wanted to learn about. It also altered the learning environment, instead of being taught at by our professor every day, we were given the freedom to read over the material, bring forth our questions, and then find the answer for ourselves and bring it to class. Approaching material in a way that emphasized the process of learning instead of just memorizing the material to get an “A” helped instill the love of learning that is vital to a liberal arts education.

This  love of learning was such an important part of this course. If I’m being honest, these four years of undergrad have been tough. As a chemistry and biology double major, I have spent endless hours going over material, reading, studying, doing homework… it has been a lot of work. And extremely stressful, as we constantly have our minds focused on what is ahead and how our grades will affect our future. I was starting to ask myself why in the world I ever wanted to be a science major. And then neurochemistry reminded me why. The excitement of finally discovering how a pathway works or how different molecules interact with each other reminded me that learning is not just about getting good grades. I found myself drawing connections from the papers we read to concepts I had learned during my years at Concordia. When you can finally apply what you have learned in the many biology and chemistry courses to “real life” topics such as neurological diseases, you begin to feel the value of your knowledge. Before neurochemistry, I felt as though I knew a bunch of random information about receptors and enzymes, but after this course I now realize how important that knowledge is. For this reason, I believe neurochemistry is the epitome of what a capstone course should be: it, for lack of a better term, caps off your college experience. It connects everything I have learned and showed me how my knowledge will be used in the field I wish to spend my life in. Neurochemistry was exactly the class I needed to round out my education and make me feel comfortable moving into the next stage of my life.

The Community Action Project also played a large role in why neurochemistry was such an enjoyable course. This project allowed us to expand our knowledge outside of the classroom. We also worked with students from a totally different discipline at Concordia, something that doesn’t happen often. Looking at an issue facing our society alongside students who approached it from a different viewpoint than us was very helpful to understanding the interdisciplinary connections all throughout our society. We had to evaluate a need and truly decide what was the best approach to helping with that need. This let us tap into each person’s expertise and allowed us to understand the need from so many different perspectives. We were really able to BREW and make a difference within our school and community, something no other class has really allowed us to do.

Overall, I really enjoyed my time in neurochemistry and I am so glad I decided to take it as my CORE capstone experience. It was so nice to be in a classroom environment where the focus was learning and discovering, not testing. I now know my semesters at Concordia have given me a wealth of knowledge that I will be able to apply not only to my future professional career, but to other aspects of my communities. I am very thankful for my liberal arts education and how it provides me with opportunities such as this course.

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Your Brain on a High Fat Diet: Is fast food really worth it?

You’re hungry, you drive to McDonald’s for lunch. You get back to your office and you decide to skip the stairs, and take the elevator. These little decisions made out of convenience don’t seem like a big deal, but what if I told you that they were, if not made in moderation. For many American’s this choice is a daily reality. The United States, as a whole is turning into a sedentary, at time lazy society filled with cheap processed food, and screens in our hands. Around 40% of adults in the US are considered obese, meaning they have a BMI (body mass index) of over 30. In 2016, it was reported that 1 in 5 children are considered obese. With a growing number of obese individuals America needs to do something to help treat this disease, and you can help make a change.

What is BMI?

In order to understand obesity, you first need to understand what BMI is. Your BMI or body mass index is calculated by taking a person’s weight, in kilograms, divided by their height in meters squared. Body mass index measures the “fatness” of a person’s body.

  • BMI below 18.5: This is considered underweight
  • BMI of 18.5 to < 25: This is the normal range
  • BMI of 25 to < 30: This falls into the overweight range
  • BMI of 30 or higher: This is the obese range, and there are three sub-classes
    • Class 1 Obesity: This is a BMI of 30 to < 35
    • Class 2 Obesity: A BMI of 35 to < 40
    • Class 3 Obesity/Extreme Obesity: This is a BMI of 40 or higher

However, it should be noted that according to health professionals, a person’s BMI is used as a screening tool and is not a complete indicator of a person’s health.

Obesity and Your Brain

While it might sound strange, obesity can be considered a brain disease. When a person is obese physiological changes can take place, which effect the insulin and leptin receptor resistance, which in turn can lead to over eating. Besides these changes, obesity can inhibit pathways associated with appetite suppression. Saturated fatty acid molecules, which are found in large amounts in processed foods, can freely cross, and in turn accumulate with in brain tissue. This accumulation leads to the activation of inflammatory pathways. The inflammation can then lead to further insulin resistance, and the decreased ability to use insulin for energy.

Insulin Resistance

Besides leading to diabetes, insulin resistance can lead to the inhibition of POMC neurons. These neurons, when working normally, are activated after we eat and tell us when to stop eating. When POMC neurons are inhibited this function is lost, causing us to continually eat. AgRP is another important neuron in obesity’s story. This neuron under normal circumstances, when you are hungry, tells the body to eat in order to gain energy. When insulin resistance occurs the body is no longer in balance. This imbalance leads to an increase ratio of POMC and AgRP in the brain.

 

Everything in Moderation

You’ve probably heard the saying “everything in moderation,” but when it comes to treating and or preventing obesity this saying could not be any truer. I would never tell anyone to not eat pizza, donuts, or french fries. That would be hypocritical of me. I love these foods as much as the next person. Rather, eat these in moderation. Finals and Christmas are upon us, and are usually filled with high-fat foods along with stress-eating. We can’t get ride of sugary and high fat foods, but we can exercise and eat better. Next time you are stocking up on snacks, pick some fruits or vegetables instead of that extra bag of chips. Your body will thank you, and so will your future self.

 

Images:

Image 1: https://www.lalpathlabs.com/blog/why-is-obesity-a-health-problem/

Image 2: http://www.stigmainhealth.com/bmi-calculator/

Image 3:  https://moodle.cord.edu/pluginfile.php/733031/mod_resource/content/1/hypothalamic%20inflammation%20in%20obesity%20and%20metabolic%20disease.pdf

Image 4: https://ltthompson.wordpress.com/page/2/?archives-list=1

Neurochem Semester Story

The Neurochemistry capstone course brought together all of Concordia’s goals for liberal learning and provided me with a unique and meaningful capstone experience. Through weekly readings, discussions, and blog posts along with a Community Action Project bringing together neurochemistry and social work students we were able to learn and apply neurochemistry in a variety of contexts.

 

  1. Instill a love for learning

During this course, we were able to rank topics according to our interests to form groups for a project that, throughout the semester, were going to work and engage the community in. I found the whole project inspiring, especially as it took the knowledge we learned in class and gave it a purpose outside of the course. Along with this, I found myself staying interested throughout this course as each week we tackled a new topic not for the goal of just learning it but engaging this knowledge to discuss the implications of what we had learned to medicine, the well-being of our community, and science.

  1. Develop foundational skills and transferable intellectual capacities

I think one extremely important intellectual capacity I gained from this course is how to successfully read and understand scientific literature. Being able to read a difficult paper and pick out the parts that make sense, and do further research to get the parts that don’t make sense is something I will be need all the time in my future. Another foundational skill we practiced in this class is critical thinking. Making connections between parts of the papers, topics from different weeks, and our past knowledge of science was all a part of the learning process. This is a skill that is needed in all careers and areas of study.

  1. Develop an understanding of disciplinary, interdisciplinary and intercultural perspectives and their connections

Working together with students studying Social Work during our Community Action Project helped us to build an interdisciplinary project. This was worthwhile, especially with my teams project focusing on mental health, as we had to focus on the science of mental health, but also the resources and supports important at our campus and in the community. During weekly discussions, we were also encouraged to answer questions posed by discussion leaders that often involved thinking about a variety of implications and perspectives.

  1. Cultivate an examined cultural, ethical, physical and spiritual self-understanding

Throughout this semester, I was personally able to develop further my passion for understanding and impacting the fields of mental health and psychology, especially through our community action project. I have also been able to develop my learning style and determining which learning techniques are helpful for understanding and engaging scientific knowledge.

  1. Encourage responsible participation in the world

The projects we worked on throughout the semester encouraged us to engage with our campus community and the greater area of Fargo and Moorhead.

Alyssa Dalen, Concordia class of 2020

 

NeuroChem at Concordia

As a capstone to my Neuroscience major at Concordia College, Neurochemistry has addressed all five of the college goals for liberal learning. As a course, I believe we have discussed as many diverse topics as possible and related them to the topic of the course, neurochemistry. We learned about and discussed everything from Alzheimer’s Disease to medical marijuana, while also addressing each topic from our unique perspectives. Within the course, we had psychology students, neuroscience students, chemistry students, biology students, pre-pharmacy students, pre-medical students, musicians, athletes, student leaders, and a whole gambit of personal experiences to draw from.

The way the course was designed allowed us all the opportunity to share our perspectives in the academic environment. Each week, we read a research article on the neurochemistry of a different topic. During discussion and recap of the article on Monday, students would ask and choose questions to research for the next class period. On Wednesdays, students brought what they found to class and shared it in a “speed-dating” format. After addressing multiple different aspects of each topic, we all participated and led large class discussions on Fridays. Following discussion, we took our new insights and formed our complete understanding of each topic into a blog post to share our knowledge to those around us.

Instill a love of learning. The course material and the way in which the course was designed and implemented contributed to students meeting the goals of liberal learning. The first goal of liberal learning, as identified by Concordia, is to “instill a love of learning.” Neurochemistry easily accomplished this first goal. It is not hard to get excited about discussing the mysteries of the brain, especially when the discussion relates to hot topics such as mental illness and addiction. Likewise, the topics discussed in this course all affect us in different ways, making them interesting to study. Gaining understanding to the neural mechanisms of issues that are present in society only excites me more about continuing my education in neuropsychology.

Develop foundational skills and transferable intellectual capabilities. The second goal of liberal learning, “developing foundational skills and transferable intellectual capabilities,” was accomplished by this course through the design of the course. Reading a neurochemically-based research article each weeks helps students fine tune their ability to read and comprehend dense literature. Likewise, the community outreach project portion of this course taught us how to address the needs of issues within the community while collaborating with our peers.

Develop an understanding of disciplinary, interdisciplinary, and intercultural perspectives. The third goal of liberal learning as defined by the college, “developing an understanding of disciplinary, interdisciplinary and intercultural perspectives and their connections,” reached success through discussion of our different backgrounds and personal experiences. As addressed earlier, the students in this class were not from many different disciplines and personal experiences or identities.

BREW. In the same way, the fourth goal of liberal learning was addressed, “cultivate an examined cultural, ethical, physical and spiritual self-understanding.” Likewise, this goal was reached by our discussion of different perspectives and populations within the topics we researched each week. Socioeconomic status, religion, and race were all common themes brought up in group discussions.

The fifth and final goal of liberal learning, “encourage responsible participation in the world,” came through in not only our class discussions, but our community action projects. As an aspect of the course, we worked in groups to address an issue within the community related to mental illness, PTSD, Alzheimer’s Disease, or Autism Spectrum Disorder. The community action project that the group I was part of addressed the stigma of mental health on campus. At Concordia, there is a pressure to identify as a “Happy Cobber.” The phrase is well-known among students and distressful to many. Additionally, the college Instagram account at the beginning of the year posted a photo of Kernel, the school mascot, leaning against the words, “NO BAD DAYS.” Within a few hours, the post was deleted due to the backlash of students who thought it was wrong for the college to insinuate that students cannot have bad days or that the statement was invalidating the experience of many Cobbers with mental health conditions. Knowing these things, the goal of our project was to raise awareness of the realness of mental health on campus through a social media takeover on Concordia’s official Instagram page. We addressed the “Happy Cobber” and proposed the “Real Cobber.” I recorded and edited videos of students, faculty, and community resources discussing the stigma of mental health on campus, the resources available to students on and off campus, and the message that participants had for individuals struggling with mental health. All of these videos were posted on the college Instagram story, and for the first time, a discussion of mental health was coming from the official Concordia social media profile. Likewise, we tabled during Mental Health Awareness week as a group to raise advocate against the stigma of mental health, raise awareness of the neurochemistry behind mental illness, and provide information regarding on and off campus resources. Due to its impact and originality, this community action project was likely my favorite way that I have became responsibly engaged in the world for a class project during my time at Concordia.

Neurochemistry is a successful capstone experience because it not only provides new information and pushes students academically, but it also relies on the previous experiences and perspectives of students while encouraging them to become responsibly engaged in the world around them.  

 

Our Neurochemistry Family

The Neurochemistry course has allowed me to become more aware of the many impacts of the brain on the rest of the body. Neurochemistry at Concordia gave me an opportunity to explore various topics having to do with the connections between the brain and many different diagnoses and diseases. I have loved being able to relate many of the courses I have taken at Concordia come together in this class, including Anatomy, Psychology, other Neuroscience courses, Biology, and Chemistry and use them to understand complex diseases. I have also truly enjoyed working with my peers to study the pathways of the brain in a directed manner and as Dr. Mach would say “solve all of the world’s problems”. Having a Capstone course that requires me to use all of the knowledge I have gained from Concordia was an amazing way to end my college career, as I am not only ending my semester, but also my college career. 

After taking many neuroscience courses in the past, all of which were mostly just lab and lecture-based, I was interested to see how Neurochemistry was going to work as a capstone course prior to taking the class. However, after taking the course, I realized how much more it focused on the big picture, creating an environment for understanding and discussion, and forcing the class to see everything as being interconnected. Each week brought a new topic and allowed me to learn more and more about diseases I thought I had been knowledgeable about previously. I felt myself growing more in the Neuroscience field and applying what I have learned in all of my classes at Concordia to each specific disease. 

Each week, we had a rotating schedule which consisted of reading and discussing and article, researching and sharing about our questions from the article, and a final discussion about our opinions on the disease or diagnosis of study. This allowed us to look at each topic from a variety of different ways and fully understand the impact and relationships going on for each disease. I really enjoyed this aspect of Neurochemistry as it helped me to learn about the disease from many different perspectives and see all sides of every argument. In addition to the articles, we had two exams to test our abilities on how to best analyze and understand scientific articles, which was very beneficial and challenged me to think more methodically under stress. 

The final most important part of the course was the Community Action Project, where we were able to combine with Social Work students and focus on one topic that is either very popular or controversial in Neurochemistry. The topics chosen by our classes were Alzheimer’s, Autism, Anxiety/PTSD, and Mental Health. The CAP group that I was a part of focused on mental health and this was one of the most impactful experiences of my Neurochemistry experience. Being able to work closely with students from many different majors, minors, and backgrounds to find a way to implement a way to target the issue of mental health and lack of awareness into the college community. I loved being given the freedom to collaborate and decide a final project that our group thought was best in order to address this issue for college students at Concordia. Being able to see the ways mental health impacts college students and faculty through surveys and interviews really opened my eyes up more the issue and I learned so much from all of our research before and during Mental Health Awareness week.

Overall, Neurochemistry taught me an immense amount about how to address issues, how to collaborate with students, faculty, and community members, and how to research common issues and find potential solutions for them. I truly enjoyed this course and especially enjoyed the other people in it. Concordia has five goals that they use to focus their education on, all of which I found to be applicable to my experience in the Neurochemistry capstone course. The first is to instill a love in learning. As I have mentioned up extensively up to this point in my blog, this course truly made me more interested in a multitude of topics, to the point where I would do extra research to find out the answers to my questions and to just continue learning MORE. The second goal is to develop foundational skills and transferable intellectual capacities. This course helped me to improve many of the skills I already had, as well as to develop new skills that will help me to succeed in the future. Some of these skills include communication, responsibility, intelligence, understanding, patience, and being more hard-working. All of these skills will apply to my future career as a Physical Therapist and will help me to continuously improve upon who I am as a student and person. The third goal is to develop an understanding of various perspectives and their connections. This goal was displayed in many different ways, but especially in all of the discussions that were included in Neurochemistry, whether during our weekly discussions about articles, our CAP group projects, or our various research on many different topics. Finding and understanding different perspectives about all of these topics were key in making me enjoy the class as much as I did. I have really grown to appreciate learning from all points of view, especially those different from my own, as it allows me to fully understand each topic from all different sides and see it as a bigger picture. The fourth goal is to cultivate a greater self-understanding. Neurochemistry helped to put me personally in each situation, disease, and diagnosis, and look at them from the view of the physician, caretaker, victim, patient, etc. This has created a much more well-rounded perspective not only on things related to the brain and body, but just all things in general. I have found myself stopping to think about things in many more ways than I had before taking the course and feel as though I have become much more able to see where each person is coming from. Finally, the fifth goal is to encourage responsible participation in the world. I feel that this goal really came in to play with our CAP group participation in mental health week. We combined community resources, campus resources, opinions from students and faculty, and the research of the neuroscience behind mental health disorders to create a much wider understanding of mental health all over the Concordia campus. 

Neurochemistry changed my perspective on many issues and allowed me to become much more knowledgeable about not just neuroscience, but many other life skills as well. I am excited to use what I have learned in this course to transfer to future experiences. I know that what Dr. Mach has taught us will help extremely in the future and will be able to continue to be applied to my future education and career. Working with the other students in my class and Dr. Mach was the best way to end my time here at Concordia, and I feel more like a family then just another class. I will forever remember my time in Neurochemistry, the skills I learned, and the people I spent it with.

This is Your Brain on Food

Discussing obesity becomes difficult when considering every side of the “argument.” Between social advocacy to the neurochemistry of weight, many perspectives have to be considered. Body positivity has been a growing concept within society over the past decade, and I would argue that this is a good thing. Often, body image is a socially derived concept and is not just the individual’s physical appearance, but how the individual perceives themselves. In many cases, due to societal pressures, people perceive themselves as heavier than they actually are. These perceptions may lead to mental health concerns, primarily the development of eating disorders. Reward related brain areas are involved in eating disorders. Specifically, in bulimia nervosa, bingeing on foods that taste good leads to the release of dopamine, while the purging of food reduces the signal or effectiveness of acetylcholine. Acetylcholine signaling normally indicates when an individual is full or nutritionally satisfied. In anorexia nervosa, research has suggested that food intake following periods of starvation increases the amount and effect of dopamine within the reward pathway. In cases of anorexia, individuals tend to have a variant of the 5HT2A serotonin receptor responsible for releasing too much serotonin during non-starvation periods. Researchers hypothesize that an individual with anorexia may feel better during a starvation period because it reduces the amount of serotonin. In contrast, individuals with bulimia and binge eating disorder experience lower-than-normal levels of serotonin. In these cases, the individual tends to excessively eat in order to increase serotonin and decrease depressed mood.

 

Additional important concepts discussed within the neurochemistry of weight include high fat diets, weight cycling, genetics, and diabetes. A high fat diet is characterized by the intake of foods high in calories and saturated fatty acids. In the brain, intake of a high fat diet has been shown to lead to apoptosis, or cell death, in rats. Specifically, these neural changes are occurring in the hypothalamus, the brain region responsible for regulatory functions such as eating, drinking, and homeostasis. Once these changes occur, weight cycling begins. People are genetically dispositioned to a certain weight or to becoming overweight and weight cycling aids in this process. Once an individual reaches a certain weight, they may lose weight but be unable to keep weight off, returning to their original weight. These processes are impacted by leptin signaling and energy in the hypothalamus. Individuals require food for energy, but during weight cycling, this energy balance is disturbed during the fluctuation of leptin. These concepts also contribute to diabetes. Approximately 30% of people who are medically categorized as “overweight” have Type II Diabetes. Conversely, 85% of people with Type II Diabetes are categorized as “overweight.” This does not mean that diabetes and weight are inherently related. To develop Type II Diabetes, in many cases, a prolonged consumption of a high fat diet leads to fat accumulation and ultimately, insulin resistance. As we know from previous topics discussed in this course, insulin resistance in the brain increases an individual’s susceptibility to neurodegenerative diseases. Likewise, research has identified that diet and the gut-brain axis must be considered when discussing the onset of disease, mental illness, and neurodegenerative disease.

Although we understand the issue of obesity from a medical perspective, the social aspect must also be considered. In many cases, individuals who are deemed overweight by physicians do not receive proper medical care. Likewise, individuals of a higher BMI are less likely to seek medical advice, typically due to stigma and the fear of being judged. As someone who has worked in a hospital, I have seen these tendencies first-hand. I have heard nurses comment about a patient’s weight in a derogatory manner, often blaming the patient for their health concerns. As many of us prepare to enter the medical field in some way, we need to consider all aspects of someone’s condition, not just their weight. People are more than their BMI, and typically, weight is a genetically-determined factor within the whole scheme of an individual’s wellness.  

 

http://2018neurochem.pbworks.com/w/page/128067411/Hypothalamic%20inflammation%20in%20obesity%20and%20metabolic%20disease

https://www.psychologytoday.com/us/articles/199702/body-image-in-america-survey-results

 

The End of a Chapter

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As this class comes to a close, it marks not only the end of a semester, but the end of my undergraduate career; a bittersweet feeling as this chapter comes to a close. Thought my college career, the majority of my courses have been largely content based. Having the hopes of going to medical school, my nights were spent continually reading though notes in an attempt to memorize rather than apply as my future was dependent on my GPA. Neurochemistry was a breath of fresh air as I end my time here at Concordia.

Neurochemistry was different from all other classes I have taken, and in the best way possible. This course was largely applicable to both my future and everyday life, it allowed for open discussion and conversation rather than lecture and provided adequate time for deeper understanding while still challenging my knowledge and capabilities.

As I am dedicating my life to a future in medicine, this course helped to again spark my love for both learning and science. Rather than demanding memorization, Neurochemistry allowed for understanding and applicability. To be quite honest, before this class I was getting very burnt out on school. Combining late nights of memorization with the constant worry of grades, all love of learning became lost amidst the concern for my future. Neurochemistry was different in that it allowed time for comprehension and questions while still expanding my knowledge of the world around me. With the ability to spend an entire week on one scientific paper, we not only learned the information better, but were taught how to ask questions and move forward with our scientific curiosity. The skills that this developed are foundational to not only learning, but future success in all aspects of life as progress stems from the ability to ask questions and think critically.

Neurochemistry was also a course that was greatly transferable to many disciplines of learning. Beyond just the scientific aspect that you would expect in a course such as this, it taught a lot about social aspects of life as well. By learning about treatment, diagnoses, and having adult conversation about the emotions that surround each and every one of these diseases, I feel as if I am now better prepared to handle situations where either my knowledge on the subject is lacking, or emotional understanding is crucial. This gives me better cultural perspective of what other people and deal with in their lives, as well as how to help those around me who are struggling. It was also fun to see how our knowledge of the diseases were able to coincide with information we as science major have learned in previous courses.

Overall, I believe that this Neurochemistry course can most definitely be qualified as a capstone course. Not only do I feel that I am coming out of this class with greater knowledge concerning the brain, emotional, and social relationships, but I have been both humbled and sparked. Humbled in the sense that I now have a better grasp on how lucky I am to live the healthy life that I do and sparked in the sense that I feel that with my greater understanding I have the capabilities to make a difference through my career. I feel for the first time that after taking this class, I am now prepared to become responsibly engaged in the world as I head out into the “real world.”

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Obesity and the Western Diet

Obesity has become an epidemic across the world, but especially in the Western world. Specifically in America, there has been an extreme increase in cases of obesity across the nation. 2/3 of adults and 1/3 of children in America are overweight or obese, which results in about half of the total population. The amount of children who are obese has tripled since the 1970’s. The Western diet is characterized by:

  • overconsumption of sugars
  • lots of saturated fats
  • excessive animal protein
  • reduced intake of plant-based fibers

Nearly 3/4 of Americans are not eating enough fruits and vegetables (plant-based) and consume over 1/2 of their calories by eating “ultra-processed” foods, which contain lots of sodium, trans fats, and artificial sweeteners. These foods are more convenient to purchase and eat as they are packaged for the on-the-go lifestyle and are often cheaper. Examples of ultra-processed foods common in the Western diet include:

  • white bread
  • potato chips
  • frozen pizza
  • soft drinks
  • candy

Not only does the Western diet increase the risk of becoming obese, but it also increases the risk of becoming diagnosed with chronic diseases and the morbidity rate. Nearly 1/2 of the adults in the United States have one or more chronic diseases related to a poor diet. This is due to the increase of fatty, processed foods in our diet mixed with decreased exercise and sleep. 

Our gut health and immune system suffer due to the poor diets of the Wester world. Having a high-fat and high-sugar diet kills off the necessary bacteria in our body’s microbiome, causing the body systems to fall out of homeostasis. When our gut microbiome is compromised, diseases, such as diabetes, heart disease, and hypertension, can occur. In addition, our immune system struggles to differentiate between good and bad bacteria, causing an inflammatory response to be triggered. This inflammation causes the body to attack itself and stimulate an autoimmune disease or the inflammation that characterizes obesity.

Taking care of our gut health is crucial to control the Western diet. Some actions our nation needs to take in order to increase health awareness are:

  • leading an active and healthy lifestyle
  • eating less salt and sugar
  • keeping gut healthy and eating more plant-based foods
  • replacing bad fat with healthy fat
  • choosing healthier processed foods such as: 
    • canned vegetables
    • frozen fruits and vegetables
    • whole grain pasta
    • nuts and nut butter
    • yogurts
    • canned and frozen fish

In order to battle the obesity epidemic, we have to target the youth and educate them on how to live a healthy lifestyle at a young age. If obesity is connected to the brain, teaching them how to best treat their body at a younger age will help them to develop healthy skills sooner and retain them for a longer period of time.

Since obesity affects a person’s health greatly, children who are obese with be at greater health risk. Eating healthy food, exercising, getting enough sleep, and having strong relationships are key to avoiding obesity. As obesity has a strong genetic factor, it is important to combat it with these techniques.

“The Gang Does Neurochemistry”

“Neurochemistry. What a beautiful word. Chemistry of the brain. It sounds so complex and I’m sure it is.” This is what I thought when I saw this class when I was registering last spring. I really had no idea about what was going on in the brain, I’ve never taken another neuro class so I was really excited to learn about it. I was pleasantly surprised to find out that I had a few great friends that were taking the class as well. I was even more pleasantly surprised to find out that so many of the people in this class that I did not know before have now grown to be my friends. All of this along with learning something new? I couldn’t be happier.

I really enjoyed the community action project that we did with the social work students. So many times in our articles we look at cold, hard, scientific facts that we can use to help treat ailments that come out of some brain problem. However, the social work students remind us to view these people as a whole person, not just a patient in need of our help. This helped to show me that we have to do what is best for the person, not just treat them for the sake of treating them.

My favorite part of neurochemistry was our Friday discussions. Every Friday, we would go sit in some comfortable chairs and discuss what we had learned during the week about our paper. I loved this so much because I got to see so many different perspectives on the same idea. I got to see how somebody would treat a disease as a social issue and how we could possibly solve some of these issues. It gives everyone a good chance to voice some opinions, observations, or shed new light on something that others haven’t thought of before.

https://twitter.com/kernelcobb/status/76844603683661313

Concordia College has Five Goals for Liberal Learning:

  • Instill a love for learning

Neurochemistry helped to instill a love for learning in our whole class. Every week there were so many things that were not understood about the paper, so we would take time to ask these questions, look for the answers, and share them with the class.

  • Develop foundational skills and transferable intellectual capacities

For me, I found this class to help me work on my critical thinking skills; especially in exams when we were given a problem and we had to deduce how the pathway works and what was going wrong. Regardless of where we will be in our lives in the future, we will likely be working in some type of team. Doing the community action project, doing group discussions, and working together on papers will all help us in the future.

  • Develop an understanding of disciplinary, interdisciplinary, and intercultural perspectives and their connections

This course helped me to understand different brain disease and how they pervade societally and culturally in our world. We learned about Autism, Alzheimer’s, Anxiety, Schizophrenia, Addiction, Endocannabinoids, ALS, and obesity. All of these are prevalent in our world today and we are trying to connect them back to the brain. If we can better understand these things, we can better treat or fix these problems.

  • Cultivate an examined cultural, ethical, physical, and spiritual self-understanding

The thing that gave me the best self-understanding throughout this class was writing these blogs. It really made me think about how I felt with the issue, what I think should be done, and what I still do not really understand. It’s really important to reflect upon your studies to think about these things. Though these blogs may have been “required”, I found myself looking forward to writing them because then I could think back upon the week and about what I learned.

  • Encourage responsible participation in the world.

Together with all of the above, I believe that this class has encouraged me to BREW along with many other classes that I have taken in my time here at Concordia College.

So now after reflecting on my time in Neurochemistry I can definitively say that not only is Neurochemistry a beautiful word that is a complex and difficult problem, it is also more important in our world than I could have ever known because of all of its connections and my favorite class that I took at Concordia. I look forward to seeing what my classmates do in their futures and I hope that they all remember this class the same I will. I’m going to remember it as the time that “The Gang Does Neurochemistry”.

Underlying Value in Concordia College’s Neurochemistry Course

The neurochemistry course at Concordia College has been a pleasure to be a part of as it has solidified my interest in the mystery of the brain and led me to become a better scientist. As a neuroscience major, taking this class is a requirement for graduation. Although, I would recommend it to anyone willing to take on the challenge of understanding more about the fantastically complex interactions within the nervous system. I enjoyed discussing these brain pathways with a broad variety of individuals from an assortment of different backgrounds. This class allowed many different perspectives to be integrated into the ultimate interdisciplinary subject, neuroscience.

I have taken several classes involving the nervous system and brain, but none have given me the same sense of wonder or passion as provided from neurochemistry. It was a rewarding feeling to have finally accomplished all of the dirty work of understanding the basics of neuroscience and to apply it to a real-life problem. All too often do we get the sense that there is no point to anything we are learning in core curriculum classes. I spent countless hours studying brain regions and neural mechanisms of disease and got no sense of connection with the real world. But neurochemistry has made me realize what college is all about. This course allowed me to bridge the gap between what I know academically and what I know about humanity. There are a seemingly limitless number of diseases that can affect one’s brain and negatively impact their quality of life. Knowing more about just a handful of these diseases has provided me with a huge sense of fulfillment.

Another unique quality of this class was the emphasis on self-fulfillment rather than motivation through grades. Group projects in most classes involves splitting up an assignment, doing your own part, and never discussing or meeting with your group members. Although this can often result in good grades, no experiential learning occurs from it. Communication with others and self-efficacy are crucial skills to learn for our careers and the neurochemistry course has challenged us to pursue these goals.  Neurochemistry is set up in a different way from most classes because it is more than just a grade on the line. We were not pushed to get a project done by its due date just to get a grade and be done with it. We worked on it because we had intrinsic motivation to create the best possible product. It gives me immense satisfaction to know that when I work hard on a difficult task, I can come out with something that has use in the real world. This goes for both group work and independent research. After taking this class, I am much more prepared to work on tasks independent from immediate reward.

The main project in this class was the community action project. This project involved a group of 8 people coming up with a plan to better the community. The issue we tried to solve was the fact that caregivers of trauma victims are not really educated on how the brain is involved with PTSD. We decided to reach out to a facility that cares for trauma victims in Fargo called Fraser. Our plan was to find a way to educate these workers about the neurobiology of the disease to help them achieve a better understanding of what is going on in the brains of these victims. Although the idea was simple, the difficult part of this task was to integrate just enough of what we learned in neurochemistry without overwhelming the workers with irrelevant knowledge. Overall, I think this project went well and the workers seemed pleased to have some education on this subject.

This community action project was another example of how neurochemistry has allowed me apply what I know in neuroscience to a real life problem. Before this project, my communication of science has mostly been through presentations to an audience that already has a solid understanding of what I was talking about. This time, I had to analyze the background of my audience and tailor my communication to a level that would provide the most benefit. This skill is important in any career as we all talk to people of various educational backgrounds and need to develop a sense of how to convey our thoughts effectively.

Something I really enjoyed in this class was the set schedule of events that happened each week. Mondays were set aside for initial discussion of the week’s paper and answering any questions about it. On Wednesdays we would discuss specific topics of the paper in more detail, and of Fridays a class discussion would be held focusing on the big picture implications of what we talked about earlier in the week. I enjoyed how we knew what to expect each class period and knew exactly what to prepare for. Also, these weekly discussions have allowed me to really get to know the entire class more than I have in any other course. I think it is very important to have a close relationship with colleagues and the neurochemistry course has exercised this skill. When a group of people know each other well, the final product they produce will often be better because each person finds out where they fit on the team.

I hope to use skills I learned in this class in the future as I believe many of them are useful in daily life. With the plethora of knowledge about neurochemistry I learned aside, the basic human skills to apply to the real world made this class worth it for me. It is true that I did learn a lot about brain diseases and ways to fix or improve them, but I think the biggest thing I can take away from this class is to never be satisfied with what I know. The weekly research we did on specific topics has made me realize that we will never be able to fully understand a topic and that there is always more research to do. As I pursue my career in the field of neuroscience research, I will keep in mind what I have learned from my capstone experience of neurochemistry at Concordia College.

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