Locking Away Mental Illness

In 1963, President John F. Kennedy signed into law a landmark piece of legislation titled the Community Mental Health Act (CMHA). Its purpose was to redirect funds from state-run asylums and into mental health centers within communities.  The ultimate goal was for patients from these state-run institutions to be reintroduced into their communities and become contributing members of society. Riding on the waves of this legislation, other laws passed throughout the 1970’s and 80’s which ultimately dismantled state-run mental asylums altogether. Before these laws were passed, there was mounting evidence coming out that these institutions were riddled poor oversight and care for patients.
While these laws are hailed as major steps in mental health rights, these laws weren’t perfect by any means. While the CMHA had good intentions, funding for these community health centers never came and many patients became homeless as health centers became overburdened. Over the years, many of these patients were thrown in jail or prison.  The Bureau of Justice Statistics estimated in 2007 that 705,600 people with mental illnesses were in either jail or prison. This includes people with severe mental illnesses such as schizophrenia or bipolar disorder. Furthermore, the environment of jail or prison only exacerbates many of the problems of mental illness instead of treating it. There are some mental illnesses such as paraphilias or borderline personality disorder coincide with criminality. However, the vast majority of people with mental illnesses are more likely to harm themselves than others.
Sources:

  1. https://www.washingtonpost.com/news/wonk/wp/2015/04/30/a-shocking-number-of-mentally-ill-americans-end-up-in-prisons-instead-of-psychiatric-hospitals/?utm_term=.4361a89d90d6
  2. http://www.huffingtonpost.com/dustin-demoss/prison-mental-illness_b_6867988.html

An Alternate View of Schizophrenia

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The overall issue with Schizophrenia comes during development in many cases. Of course, there are always different cases that may involve drug use to induce this condition. After reading several articles covering the neural pathways involved, it can be concluded that the cause is not exactly known at this point. For those that develop Schizophrenia that is not induced by drug use, a great deal of the damage leading up to their conditions has been hypothesized to be acquired during development.

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                It is important for those in the general public to be understanding of people that have Schizophrenia because this condition is not understood well enough in the science community for many of these people to receive the treatments they may be needing. Schizophrenia is an interesting disorder because it has such a broad range of symptoms and thresholds. Some people may be hearing voices and seeing objects or even people that aren’t present. Much research has contributed these hallucinations to overstimulation of the visual and auditory cortices of the brain. Furthermore, many of those struggling with Schizophrenia have an altered sense of reality which is extremely difficult for them to cope with because they do not view many situations in the same way others do. Currently, some of the best methods of treatment for Schizophrenia are rooted in coping methods along with the pharmaceuticals that aid in treating the manic episodes.
Image result for voices ryan reynolds netflix
After researching Schizophrenia, I happened to find a newer movie called, “Voices” featuring Ryan Reynolds which although entertaining and twisted, provided me with an alternative view of how to look at Schizophrenia. As a backstory, the character played by Reynolds in the movie was diagnosed with Schizophrenia and the entire movie was narrated from his perspective on how his interactions at work normally went and how he had an altered view of situations compared to his coworkers. To provide an example without ruining the movie, Reynolds’ character lives on his own and through his eyes, his apartment appears to be spotlessly clean and everything seems normal. When the perspective shifts to the people entering his apartment, we find that his apartment is a disorganized disaster. He also has another key symptom of Schizophrenia that with his ability to speak to his two pets that have two completely different personalities through his eyes. As other people meet his animals they are unable to speak and these conversations with the animals are uncontrolled hallucinations.
The most difficult part of Schizophrenia is that there is no definite cure for this disorder. Many people with Schizophrenia will live their whole life treating their symptoms but will never be free of this burden. Because of the many different areas of the brain associated with Schizophrenia, it is difficult for researchers to find a prominent treatment method because each patient is different therefore adding a great challenge. Going back to the beginning, another piece that adds difficulty with research is that because Schizophrenia is involved with development, researchers can’t study those with Schizophrenia until they are in their 20s which is the average age when most Schizophrenia cases are diagnosed. At this point, most development is finished and finding the culprit of the disorder is much more difficult. Where we stand right now, researchers have many hypotheses on what exactly is going wrong during development, but there is a great amount of work to be done yet.

Three Things You Probably Didn’t Know About Schizophrenia

 
Up until recently, my knowledge of the psychiatric disease, schizophrenia, was pretty limited, and I think many others can relate. All I really knew was that common symptoms include hallucinations and that it’s commonly diagnosed later in life. Over the past year, I have taken up more of an interest in mental health and the associated stigmas attached to disorders. In doing so I have learned SO much about different mental illnesses that have completely changed how I now think about them and affected individuals. This knowledge is incredibly important in the reduction of negative stigmas revolving around mental health in our society. So, my goal is to contribute to the movement by sharing some information that might help change the way you think about a specific disorder that, arguably, has some of the most severe stereotypes attached to it.

 

  1. Dysfunctional Wnt signaling is implicated in schizophrenia

Likely the most significant point – as well as with other psychiatric disorders, symptoms experienced by schizophrenic patients are NOT due to flaws in character, but rather a dysfunctional cell signaling pathway that results in significant changes in the brain. Specifically, schizophrenia has been associated with low activity or inhibition of the Wnt pathway. Normally, this pathway allows a protein called B-catenin to enter the nucleus of a cell and activate transcription of specific genes. During the transition from teenage to adult years, Wnt signaling and the expression of targeted genes play an important role in continued development, including in the brain. When this pathway is disrupted, B-catenin is destroyed before it can reach the nucleus, and those genes are not transcribed and expressed. If this occurs during that transition period, development is interfered with, and schizophrenic symptoms can result.

  1. Not all affected by schizophrenia experience the same symptoms

This should be fairly obvious, but it should still be pointed out that symptoms of schizophrenia vary from person to person. Symptoms are divided into two different categories – Positive symptoms and Negative symptoms. Positive symptoms include extra behavior such as delusional or irrational thinking, hallucinations, and disorganized speech and behavior. The negative symptoms may be less familiar or harder to detect, but should not be forgotten about. These include a lack of interest or emotion, monotony, withdrawal, and suicidal thoughts (note how these are seen in many other psychiatric diseases as well). Someone suffering from schizophrenia may experience symptoms from both categories, only positive symptoms, or only negative symptoms. In other words, not all schizophrenic patients experience hallucinations or hear voices. Symptoms and severity of the disease should be seen more as a spectrum. Yes, there are severe cases that may resemble portrayals of movies and the media, but there are many others that are more than capable of functioning in society.

  1. Concussions, and infections can induce schizophrenia

Before I get into this, I should start off by clarifying that genetic makeup is by far the biggest risk factor in developing schizophrenia. However, other factors or experienced events can also contribute to onset, such as sustained concussions and infections. For example, someone may have some gene expression associated with schizophrenia, but this does not guarantee development of the disorder will occur. Now, say this same individual sustained a concussion during their transition years. Studies suggest that the physical trauma added to genetic risk factors increases the odds of developing schizophrenia and other neurological disorders. Similarly, a woman who contracts an infection (i.e. influenza, rubella, respiratory) during pregnancy may also increase the risk of her child developing schizophrenia, as gestation is another crucial developmental period. I know, scary to think about as these situations can happen to anyone, but this again illustrates the onset of schizophrenia is multifactorial and out of the control of those who are affected.

 
 

Stopping the Stigma of Schizophrenia

How common is schizophrenia and what are some of the symptoms?
Schizophrenia is mental disorder that occurs throughout the world.  It is estimated that about 1% of the global population has schizophrenia.  That would equate to about 60-70 million people.  According to the Schizophrenia and Related Disorders Alliance of America about 3.2 million people in the United States are suspected to have the disorder.  The unusual aspect of schizophrenia is there are no “hot spots” for the disease.  This means that it is found pretty universally around the planet regardless of race or ethnicity.  Basically, someone is equally as likely to develop the disorder in the United States as someone who lives in Asia.
Schizophrenia has two different sets of symptoms that are divided into positive (extra behavior) and negative (reduced behavior).  The positive symptoms would be symptoms such as delusions, hallucinations, and disorganized thinking or speech.  So basically, these are symptoms that occur in the brain and the thought process.  The negative symptoms would be things such as neglecting personal hygiene, not being able to make eye contact, and monotone speech.  These symptoms can be seen by other people and are not constricted to the brain.
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The breakdown of the Wnt pathway as a cause of schizophrenia
In the normal human brain the Wnt pathway allows β-catenin to be produced and bind to the transcription factors of TCF and LEF.  These then allow transcription of Wnt genes that help in normal homeostatic processes.  Β-catenin is allowed to bind because the destruction complex, which includes GSK3β is inhibited by DVL.  Basically, GSK3β usually binds to β-catenin and marks it to be destroyed.  However, when DVL is active it prevents GSK3β from marking β-catenin to be destroyed.
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When the Wnt pathway is screwed up GSK3β is not deactivated, therefore β-catenin is destroyed and there are very low levels.  This means that transcription of the Wnt genes are severely reduced, which is bad for the brain.  Now there are many ways that this can occur, but it seems the most common is that excess amounts of dopamine are produced.  These active the D2 (dopamine) receptors which prevents the AKT molecule from blocking GSK3β production.  Thus leading to β-catenin suppression and schizophrenia.
The negative portrayal of schizophrenia and why that needs to change.
Now schizophrenia is a debilitating disease in the extreme forms and can cause people to become violent.  However, those are just the most extreme cases.  Most of the time people are able to manage the disease and can control themselves.  The news and movies tend to portray the most extreme cases causing this to be the public perception.  One example would be the movie American Psycho starring Christian Bale in which he goes on a killing spree as if that is the normal.
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However, according the American Psychiatric Association, “Data indicates that severe mental illness alone does not predict future violence, but that violence is associated with substance abuse, lack of psychiatric treatment, and other factors.”  From this it is clear to see that these violent episodes that are rare are not usually caused by the disorder itself, but rather some outside factor.  It is time to raise awareness about mental disorders and change the stigma so people can get the help they need.

Schizophrenics Are Violent

At least, that’s what the media will have you think. Many movies portray mental illness. I understand why—mental illness is different, and we don’t completely understand it yet, so it is interesting to explore it through movies. Movie makers often take the viewer to the extremes in order to illicit bigger reactions. Unfortunately, these movies often depict a rather unrealistic image of mental illness—consider this list.
Why does the media depict schizophrenia so negatively? In the movie The Voices the main character murders three people because he doesn’t take his medication. There are some criminal cases in which individuals that have schizophrenia are the perpetrators, but the vast majority of schizophrenics are not violent—more often they are withdrawn and introverted.
We still don’t know why schizophrenia occurs, or how to cure it. It is thought that schizophrenia occurs because one signaling method in the brain, called the Wnt pathway, is somehow inhibited. Without the Wnt pathway, an activator for brain developmental and growth (β-catenin) continually gets destroyed and never gets the chance to initiate proliferation.
Why not just use a pharmaceutical drug that always keep the Wnt pathway on? Well, this would then signal for different areas to keep growing without control… sound like a familiar problem? It sounds like tumor growth to me, which could lead to cancer. So more targeted drugs are needed to solve this problem.

You might ask then why some people have this uncontrollable Wnt signaling. Scientists don’t know yet, but there is a strong connection to genetics, mutations within cells, and external factors. It has been shown that having a family history increases the likelihood of having schizophrenia—two genes in particular, DISC1 and Akt can affect Wnt signaling. There are also cases in which different types of mutations within genes can lead to schizophrenia without a family history. External factors in the womb like prenatal infections and stressful events like famine, flood, or loss can even increase the risk of getting schizophrenia. It is most likely a combination of these factors that lead to schizophrenia.

 
Current drugs can help to regulate some of the positive symptoms (symptoms that increase behavior, like hallucinations), but there is no cure for schizophrenia. Therapy can sometimes help an individual cope with their disorder and help them to lead a more normal life. It isn’t that individual’s fault that they have this disorder, so why do we so often think of them as criminals?
Want to watch some movies where the media actually got mental disorders somewhat right? This list or this list might help you to change your view.

Is Any of This Real? the Facts Behind Schizophrenia

Is Any of This Real? The Facts Behind Schizophrenia

Many of us have seen movies or television shows that have portrayed someone with schizophrenia. However, the media portrays individuals with schizophrenia as someone who is “insane,” the “murderer,” or someone of whom to be afraid in general. But is this media portrayal anything like the truth? What exactly is schizophrenia? What causes it? Can it be treated? Here are some answers.
What is schizophrenia?
Schizophrenia is a mental illness. Just like autism, there is a spectrum of schizophrenic symptoms. Most diagnosed cases are in individuals that are 20 years or older. According to the Mayo Clinic, many symptoms of schizophrenia include hallucinations, delusions, abnormal behavior, and negative symptoms. Although these symptoms seem fairly straight forward, here’s a breakdown:
Hallucinations: These include seeing or hearing things that are not real, however, to the individual they seem completely real. Hearing voices is the most common.
Delusions: This is when the individual believes things that are not true. Some examples would be thinking that a catastrophe is about to happen, or thinking people are always talking about you.
Abnormal behavior: This includes non-goal oriented behavior, strange posture, or resistance to instructions.
Negative symptoms: This includes a lack of hygiene, social withdrawal, lack of emotion, and the inability to experience pleasure.
What causes Schizophrenia?
Schizophrenia is still being researched, however, a basic understanding has been found with a certain pathway in the brain. The Wnt pathway in the brain contains a transcription factor called β-catenin. This transcription factor is very important with development. In schizophrenic patients, the Wnt pathway is inhibited by β-catenin being tagged for deconstruction by the destruction complex GSK3β being over active. In the image below, the destruction complex normally gets inhibited by the Wnt pathway from the DVL protein, but in schizophrenia, the DVL complex does not inhibit the destruction complex and β-catenin gets destroyed. This can also happen with dopamine. The dopamine pathway inhibits a protein called AKT which also inhibits the same destruction complex. In schizophrenic patients, the dopamine pathway is overactive meaning AKT is inhibited. This doesn’t allow for the destruction complex to be turned off so β-catenin is also broken down
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Can schizophrenia be treated?
Antipsychotic drugs that are currently used target the dopamine pathway. They specifically inhibit dopamine receptors to shut off the AKT inhibition. This allows for the destruction complex to be turned off and allow β-catenin to act normally. However, these drugs don’t always treat the negative symptoms. Lithium has also been used as a treatment in the past. It is used to inhibit the GSK3β directly. Since schizophrenia is still fairly new to research, treatment is not very advanced. Hopefully in the future, more research will develop a treatment that will be able to treat all symptoms of this illness.
 
Schizophrenia is a mental illness that not many people understand. The way it is portrayed in the media even makes it seem like something of which to be afraid. However, knowing the symptoms and what is happening in the brain allows us to understand that a patient with schizophrenia is not “insane” or “crazy.” It is a mental illness just like any other mental illness.

Is Marijuana Worth the Risk?

Mental illness is a broad characterization of all the diseases that affect the mind. There are many different mental illnesses that generally do not receive enough attention as others and arguably the whole array of mental illnesses do not receive enough attention as other diseases of the human body. One of these mental illnesses I would like to discuss today is schizophrenia. According to the National Institute of Mental Health, schizophrenia is a severe disorder of the mind that affects the way a person thinks, feels, and behaves.

http://www.medscape.com/viewarticle/853005

Symptoms of schizophrenia are organized into three categories: Positive, Negative, and Cognitive Symptoms. Positive symptoms may appear as a good association but it is actually a misnomer. Positive symptoms are the symptoms or psychiatric behaviors that are not normally associated with a healthy person. Symptoms of this include Hallucinations and Delusions. Negative symptoms are disruptions of normal thoughts and emotions and these include reduced feelings of pleasure, reduced expression, reduction is speaking. Cognitive symptoms affect memory and thinking and these include loss of memory and trouble focusing or paying attention.
According to Schizophrenia and Related Disorders Alliance of America, Schizophrenia affects around 3.5 million Americans and 1.1% of the world’s population. This may not seem like a substantial number but 1.1% of the world’s population is around 70 million people. Schizophrenia is displayed by the media either through movies, TV shows, etc., in a poor manner in thinking that everyone with schizophrenia is unfit to be in the public and are aggressive and dangerous. That is why this mental illness requires more understanding and attention to remove the stigma.
Schizophrenia and many other mental illnesses are a result of chemical imbalances in your brain. An article in the International Journal of Genetics has provided insight to the actual chemical imbalances in the schizophrenic brain. They report that the Wnt and GSK3 which are small proteins that affect many cellular functions and processes in your body. In Schizophrenia Wnt binds to its receptor called “frizzled” like a lock and key mechanism and this activated downstream processes to occur like the stimulation of GSK which targets B-catenin, which is highly involved with gene-transcription, and the creation of other proteins. When GSK is activated it tags B-catenin with a marker (otherwise known as phosphorylates), and this causes B-catenin levels to decrease.
In addition to the increased levels of GSK protein there is also a decrease in levels of the AKT protein, which stops the GSK protein from affecting B-catenin. This is caused by increase levels of the neurotransmitter Dopamine binding to D2-receptors which then affect downstream processes by inhibiting AKT. Many treatments for Schizophrenia target this process. Anti-psychotic drugs help regulate AKT levels by targeting the D-2 receptors in order to stop the inhibition of AKT. Lithium is also used as a treatment for Schizophrenia and this treatment also regulate the levels of AKT.
The causes for all of these imbalances are unclear, but they could be factors affecting individuals as early as before birth. There are cases however where drugs are the inducer of schizophrenia. A common drug associated with schizophrenia is Marijuana or Cannabis, The Elements of Behavioral Health stated that nearly half of the patients diagnosed with schizophrenia abuse drugs and alcohol.

Cannabis utilizes the CB1 receptors in the endocannibinoid system and these receptors have been found in high concentrations in the brain regions implicated in schizophrenia. When these receptors are activated they release excitatory neurotransmitters such as dopamine and stop inhibitory neurotransmitters from releasing. Also, Cannabis takes a relatively long period of time for it to be stored or catalyzed in the body indicating it has a long-term prevalence after exposure. These factors implicate the biochemical pathways that Cannabis has in its relation to schizophrenia. The long latency of the molecule, the close proximity it shares with areas of the brain related to schizophrenia, and the prevalence of dopamine all show a direct relation to schizophrenia and reveal clues to a correlated relationship between the two.

I know Marijuana is a highly controversial topic but has also gained a lot of support in recent years. I have heard many arguments promoting Marijuana and all I have to add is that I do not have a judgment on Marijuana use at all I just have an assessment. I can relate if someone enjoys unwinding after a stressful day with Marijuana, but at what point does the use get to be too much? Is it when you do it everyday? Is it when you do it twice a day? Is it when you plan your day around when you have to use again? When is it?
You can find another relationship with alcohol and alcoholism or overeating. We are all mostly aware of the long-term effects of the abuse of those and what they can do to your health. I agree that there are therapeutic effects of Marijuana such as things like cannibidiol, which can treat a variety of amount of illnesses but this part of the plant, does not include the psychoactive part of the plant called THC. Other treatments that do involve using the whole plants ingredients, which include THC I think are useful as well, but at what point do you stop using it as a treatment? Is it healthy to keep using your pain medicine consistently after you are done with surgery? Also, according to the AAA Foundation for Traffic Safety Marijuana related fatal car crashes have doubled in the state of Washington since the legalization of the drug. Of course getting behind the wheel after consuming alcohol is not a good decision, does the same go for Marijuana? You can make the argument of making alcohol or tobacco illegal along the same lines of this assessment. My message to you all is at what point is enough? Is it enough when you let something control your life? Is it enough when you develop schizophrenia? When is it enough? And that question goes for anything.

Schizophrenia Around the World

Mental illnesses, such as schizophrenia, are not always well understood. Records of people with episodes and symptoms similar to schizophrenia date back to Egyptian times. However, there seems to be no difference in prevalence across races, or cultures. The origin or cause of schizophrenia is not known, although a strong genetic component is likely.

Although the word schizophrenia literally means split mind, but it is more like a split from reality. The positive or heightened effects often associated with schizophrenia are hallucinations, delusions and disorganized speech and behavior. It also has negative or under represented effects such as reduced expressions, speaking, and pleasure.

The onset of schizophrenia peaks at age 15-25 however in males the mean age is 31 and in females is 41. This gender difference may be due estrogen levels in females which may act as an endogenous antipsychotic.

Diagnosis and perception of the disease has more of a cultural connotation. Whether or not we see the symptoms of hallucinations or delusions as threatening or not depends on culture. In the US people are more likely to be described as mentally ill or schizophrenic compared to other cultures who see value in hallucinations. Some cultures see mental illness, such as schizophrenia, as a connection or communication with a super natural force.

The delusions of schizophrenic patients tend to reflect the culture form which they come. For example, someone in America is often paranoid about things such as technology or surveillance. In communities such as Ireland with a strong religious history tend to have visions of angels and a higher being and are seen as saint-like. In places such as Nigeria in which mental illness is seen as evil done by evil spirits people often have delusions of ghosts or witches.

While mental illnesses are difficult to treat, it is possible to help manage symptoms. Because mental illness varies from person to person it is important to find the right combination of drugs, therapy, and support to aid in combating schizophrenia. Interestingly, in developed nations, the fast-paced life may impede healing processes of schizophrenics because any minor disturbance can cause stress.

Antipsychotic drugs basically block dopamine receptors to help regulate abnormal dopamine levels seen in schizophrenics. However, many antipsychotics have many side effects that require monitoring. Therapy can be offered along with this to help control schizophrenic tendencies and avoiding substance abuse. Familial support is also very helpful through this process. Schizophrenia is often found in conjunction with some sort of substance abuse. Because the pathways that are affected by schizophrenia also play a role in substance abuse it can heighten the effects of that substance.

For more information please see:

https://www.nimh.nih.gov/health/topics/schizophrenia/index.shtml

http://www.mentalhealthamerica.net/conditions/schizophrenia

http://www.pbs.org/wnet/brain/episode3/cultures/

 
 
 

Do Concussions Cause Schizophrenia?

 
Short answer: no.  Long answer: yes.  Welcome to the complex world of gene-environment interactions.  
Concussions are not safe by any means; they might put you at risk for memory problems or an earlier onset of dementia.  The good news is that if your genes are healthy, a concussion probably won’t spontaneously give you schizophrenia.  The bad news is some people have hidden risk factors for the disease that can come out if conditions are right.  
Schizophrenia and autism are both spectrum disorders.  Autism can range from the mild awkwardness of Asperger’s (think Sheldon Cooper) to an inability to speak.  Like autism, schizophrenia is a little different for everyone.  Some may have negative symptoms like low IQ, memory loss, or lack of emotion.  Others have more positive symptoms like hallucinations or delusions.  
Where do these differences come from?  Schizophrenia is not a simple disease like diabetes or cystic fibrosis, where one gene is defective.  It seems like schizophrenia comes from a combination of many different gene mutations.  Obviously, having more mutations is worse, but some mutations are worse than others.  One schizophrenic patient might have a half-dozen small mutations adding up, while another patient has one or two extremely destructive mutations.  So the different combinations of risk factors explains some of the differences in severity as well as symptoms.  

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Not that kind of fugue

Stay with me while I throw one more thing into the mix: life experiences.  Remember Walter White’s “fugue state”?  He woke up with no memory of why he was standing naked in the produce aisle.  Supposedly, the stress of having terminal cancer, a disabled son, and a newborn daughter (not to mention a drug empire) was enough to drive him temporarily insane.  Walt was faking of course, but trauma can have real lasting effects on a person’s mental health.  
Imagine a freshman on the football field.  He has two mutations affecting his neurons.  Maybe a protein is slightly out of shape, or he’s overproducing some neurotransmitter.  But it’s nothing his brain can’t handle.  Then along comes a fifth-year senior with a full beard, and he’s on the ground tasting the color purple.  That hit was enough to push him over the threshold into full-blown schizophrenia.  Like many others, he starts developing symptoms at around age 20, with his high school concussion long forgotten.  
Denmark to the rescue!  Using their obsessive record keeping,  a study in 2014 had access to 100,000 participants with head trauma.  That huge sample size makes the study very reliable.  The study found that head trauma increased the risk of schizophrenia by 65%.  Other studies (here and here) have shown that a family history of schizophrenia increases the risk even more.  
 
Trauma, whether psychological or physical, has frightening power to reveal and magnify hidden disorders.  At this point in modern medicine, there’s still no way of knowing for sure who is at risk.  For now, please wear a helmet.



 

Overprescribed and Undermedicated

A recent segment from the liberal-leaning news source Vox was titled “Do I have ADHD?”. A female in her twenties believed she indeed had the disorder, but had never been diagnosed. In truth, there is no concrete answer to the question. While the DSM-5 lists criteria to diagnose the disorder, there is question as to whether the list is accurate. Current academia leans to one of two sides, that Americans are either overdiagnosed or underdiagnosed.
Of course, there are arguments to both, otherwise we’d have little debate. In one sense, the amount of drug companies offering ADHD medication increased just before the rise in diagnoses, prompting experts to create a Big Pharma conspiracy around “selling the ill, to sell the pill”. In another sense, however, studies repeatedly show that young children treated for the disorder drastically improve their learning abilities, and that the more cases found, the better our education.
But the fact of the matter remains, we can never know for sure whether someone has a mental disorder.
A blog post on Adderall addiction a few months back got me wondering, “How badly can access to psychiatric medication change someone’s life?”. Within the post a young woman candidly exposed how easy it was for her to fake a psychiatric exam to receive the drug, when she had personally never struggled with the symptoms of ADHD. She had already become addicted thanks to a friend’s stash, and had finally decided to get herself a prescription for the medication.
While there is no doubt that ADHD prescription medications have helped thousands, have they perhaps hurt just as many in the process? Even outside of the abuse that is rampant among American college students, how many children were wrongly diagnosed for simply being a hyperactive child? I remember those days. No kid wants to sit in school, church, or really sit anywhere. Children are by their nature curious beings, and they will always become distracted by the slightest piece of new information.
I am not here to say that diagnoses are all false, but statistics proves to us that misdiagnoses happen. Whether we are giving drugs to kids without a disorder, or giving the wrong drugs to kids if they have a different disorder, we are not providing them with the free life they deserve. One way or another, if the child was misdiagnosed, administration of drugs will change their lives forever.

Switching over to another psychiatric disorder, schizophrenia, there is a large push to notice symptoms, or even precursors of symptoms in children. Because schizophrenia usually does not show signs until late adolescence, it is very hard to treat in its early stage. The disorder is a result of improper brain cell growth and differentiation, and one hypothesis places the blame on low levels of a protein called beta-catenin. If recognized in childhood, could administration of this protein, or inhibition of its breakdown, help brains grow normally? But once again, how does one morally administer medication to a child without knowing for sure if they have the disorder?
While the question remains unanswered, prescription medication for schizophrenia can only be administered after symptoms show up. And if the beta-catenin hypothesis is indeed correct, by then the damage is already done. The only purpose of the medication is to treat the symptoms, not the cause, and of course it would seem improbable to add beta-catenin after the brain has finished developing.
Antipsychotics are the main treatment option for schizophrenics. These drugs are dopamine-receptor blockers (sometimes serotonin-receptor blockers) and work by “slowing down” the parts of the brain that overstimulate themselves to create the hallucinations so commonly received by schizophrenics.
But schizophrenia has other detriments. Most notably, social isolation and depression. The antipsychotics are only focused on the so-called “positive” symptoms of the disorder, and do nothing to treat these other symptoms. Even further, they unselectively block dopamine receptors, even in pathways of the brain that are undamaged from schizophrenia, leading to numerous adverse effects.
Because of all of this, schizophrenics often refuse to take medication for their disorder, and I do not blame them. As stated, the damage to the brain is already done, terrible side-effects occur, and the drug does not even treat half of the symptoms.
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I am led now to my conclusion (and the title of this article): Americans seem to be overprescribed and undermedicated. We may have doctors willing to give us all sorts of drugs that promise to improve our lives, but in the end the drugs cannot solve the issue at hand. In one case, we create a situation where abuse is rampant and misdiagnoses can alter one’s future forever, and in another we simply don’t have the science to fix the problem at hand.
While I am not against prescription drugs, and agree they do much good in the world, it is our duty to exhaust all efforts to mediate problems by non-prescription means first. Many schizophrenics learn how to live with their disorder with behavioral therapy. In other words, they know how to recognize and cope with the symptoms. But of course, cases ensue where prescription is indeed the best option. The same is with ADHD, and even other disorders. Many behavior therapies can be implemented that mediate the symptoms, and when those fail, perhaps then prescription medication should be used.

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