Endocannabinoids: CB1 Receptor and Munchies

We are all familiar with the term “the munchies,” but how does this happen?

Turns out, it has to do with the cannabinoid 1 receptors (CB1 receptors) and the effect on our appetite once there is binding with tetrahydrocannabinol (THC) to its active site. Once bound, our appetite is increased and hence the “munchies” effect.

But, where are these CB1 receptors even located?

It has been observed that there is an abundance in the cerebellum, basal ganglia, hippocampus, and dorsal primary afferent spinal cord regions of the brain. Basically, they are found all over the middle of the brain. They have also been present in some peripheral organs. For reference, here is a photo of what I meant by the middle:

What functions do cannabinoid receptors have?

Cannabinoid receptors primarily regulate and influence functions such as memory processing, pain regulation, and motor control