As of 2002 autism affected 66 out of 10,000 people in the United States. With its growing prevalence, it is becoming even more important to get a proper diagnosis for autism so that the children can receive the best treatment available. Even though autism is not curable it can be managed and children can learn how to cope if therapy is introduced early. Autism is characterized by lack of social skills, impairments in communication or particular obsessions. Since a large part of autism is a lack of empathy, a lot of the therapy that is offered for autistic individuals is behavioral therapy.
I am personally affected by autism because my youngest brother who is now 17 years of age was diagnosed with Asperger’s, a subset of autism approximately 2 or 3 years ago. Asperger’s is not as severe as autism, and individuals with this disorder are very often viewed as normal individuals, they just don’t have as many social networks because they lack the capability to relate to others in the same capacity. My brother does lack some social skills, throughout elementary school and junior high school he was often made fun of for being different. But I think one of the most distinguishing characteristics looking back now was his obsessions. His obsessions often changed over the years, but during them he was totally and completely absorbed. During his toddler years he was totally and completely obsessed with Superman, for about a year and a half he even insisted that everyone call him Superman. The next phase of his obsessions was horses; he had imaginary horses that he would call to so they could follow us every time we drove anywhere. Next was Hotwheel cars, he had over 300 at one point. Then he started collecting fishing lures, which was an odd obsession because he hates eating fish, putting worms on the hook grossed him out, and he refused to take the fish off the line. As a 10 year old, his tackle box collection would make any seasoned fisherman jealous. His current obsession is archery, no one in our family has ever introduced him to bows and arrows, but he spent his entire summer working to make money to buy a very expensive bow to just practice with since he isn’t a hunter. Often times children have passions and hobbies, but few are as dedicated and committed to them as my brother, or other autistic individuals. Perhaps their dedication is something we should envy? To have such passion about something, anything, maybe we could accomplish so much more in life and have so much more depth to our learning.
The Cure for Alcoholism….
This week’s article was about alcohol abuse, alcoholism and the mechanisms behind it. The purpose of this article was to figure out what happens when alcohol enters the brain and what parts of the brain are affected. If scientists can figure out what happens, they may be able to find drugs that can reduce alcohol dependency in alcoholics, repair brain regions that have been damaged due to alcohol and even find drugs that can cause an aversion to alcohol. However, can there really be a cure for alcoholism?
Currently there are three drugs that are approved by the FDA for alcohol treatment. The first is called Campral and it is used to reduce the withdrawal symptoms experienced by long term alcohol abusers when they stop using. It is also believed that it helps the brain return to its normal cognitive function. However this drug has many side effects such as diarrhea, vomiting and nausea. Another drug is Antabuse and when this drug is taken in conjunction with alcohol, it causes headaches, nausea, vomiting, chest pain, sweating, choking and difficulty breathing. The last medication that has been approved is called Trexan, and it inhibits the “good feeling” that people get from drinking. The downsides of this drug are that it may worsen withdrawal symptoms from alcohol and it can only be used in treatment programs.
Although there are numerous drugs on the market, I don’t think that any one of them can really be used to treat alcoholism. I personally know a recovering alcoholic and after talking to her, she said that the only thing that really truly works is when the person wants to change, and is fully committed to making that change. She has been involved in Alcoholics Anonymous for three years now and even though there have been great struggles, it has been well worth the time. When I talked to her about easy fixes and the drugs that are now available to help, she is extremely skeptical on whether or not these drugs will work on the person long term. Sure you could easily take a drug that makes you puke when you drink, but people that truly desire the alcohol, will just not take the drug. The drug that improves your brain function, could be used as an excuse to just continue drinking, because in the end, you can take a pill and be cured from any brain damage.
Therefore in my opinion, alcoholism is not an easy fix. You can’t just magically take a pill and no longer desire alcohol. Recognize that you have a problem, desire change, and take action yourself to make those changes. We can’t always rely on medicine and science to fix our problems, the power rests in our own will.
If you are or known someone who is an alcoholic and would like more information about the program Alcoholics Anonymous, you can visit their website and find a meeting location near you by clicking here: http://www.aa.org/
Heavy Metal Autism
Our paper this week talked about environmental effects and how they play into theories for how autism starts in kids. One factor that is thought to cause autism is the toxicity of heavy metals. A few examples of these metals and where they are commonly found are:
Lead – petrol, paint, batteries, certain water mains
Mercury – fillings in teeth, fish, paint, some appliances, nasal sprays and eye drops, certain vaccines.
Cadmium – Cigarettes, tires, metal plating
Arsenic – Pesticides, chicken feeds, rice, treated wood
Antimony – Carpets, flame retardant clothes
It is believed that Methyl Mercury contributes mainly to autistic development in children.
(see our class wiki)
So how then do we treat heavy metal poisoning?
Just like any other illness, we treat it with pills! Current treatments involve chelating agents. These agents bind with the heavy metals selectively and then the complex that is formed is expelled from the body by the kidneys. Some examples of Chelating agents are EDTA, DMSA, DMPS, and TTFD. EDTA however, is not used for treating autism because it can be harmful to children, and EDTA is not good for binding mercury, what is thought to be the main heavy metal poison in autistic children. DMSA and DMPS are both used and given orally. They both chelate mercury, lead and cadmium well. So they are the pills of choice for treating autism in children.
Other treatments for autism
Dr. James Neubrander has injected methlycobalamin (a form of Vitamin B12 pictured above) into patients and they have shown improvements in language ability social skills as well as in attentiveness. http://www.drneubrander.com/index.php
So there is still hope out there for parents with autistic children. It is still hard guarantee improvement however, and I’m not sure which direction we should be going with treatment. However, from what I understand, this seems to be the best hypothesis for the origins of autism. There also seems to be some treatments available that keep this theory in mind. We will see what the future brings us.
Further information can be found at http://www.autism.com
The Diversity of Alcoholism
I have for you two scenarios (These stories are not based on any person in particular, but are just general possible scenarios.)
First is a story about Edward. Edward has been a respectable CPA for the same business for the last 12 years. His family consists of his wife of ten years. A few evenings a week after a stressful day, Edward and some of his colleagues go out for a few drinks. By the time the night is over, Edward has consumed six or seven drinks and heads home. When he gets there, his wife has gone to bed. It’s late and he didn’t answer his phone. Edward storms into the bedroom and he screams and cusses at her supposed incompetence. His fury builds in the wake of his drunkenness. He takes a swing at her face. Edward is an aggressive and abusive alcoholic.
Second is a story about Lenny. Lenny is and has been a hardworking man doing construction for 25 years. He has a beautiful family of two sons, a daughter, and wife of 24 years. His family appears normal from the outside. No neighbors see any issues with the family across the street. They are just a normal working class family with a moderate income. But what cannot be seen from the outside is that each night before Lenny comes home. He stops at the bar with his buddies and has a few…then drives home. When he gets there supper’s on the table. His wife offers to make his plate, but he politely refuses. He goes back outside and underneath his workbench in the garage takes out a can beer…and another…and another…and another. Until it’s almost time for bed. This takes place day after day, week after week. Lenny is a passive alcoholic.
These two stories are different on so many levels. But the one common link between the two is the alcohol. How is it possible that alcohol can have such polar-opposite effects on two individuals as similar as these? This is a difficult question to answer and to be honest experts still don’t know.
Image from: http://usdrugstore.blog.com/alcoholism-learn-about-alcoholism-symptoms-stages-and-how-are-alcoholism-treated/
This week our neurochemistry class explored the reasons behind the behaviors that alcohol causes. Biochemically alcohol (ethanol) has an effect on all parts of the body including the nervous system. Alcohol’s complex impact on the body makes it difficult to pin point the reasons for certain behaviors. However, one effect that alcohol always seems to be true to is that of becoming uninhibited. Individuals who have had only a couple of drinks tend to show signs of uninhibitedness and “loosen up.” The truth starts coming out. Individuals become unafraid and senseless. They lose their reasoning for making good decision making. This may be the point where individuals differ in their actions. This may be why there are passive drunks, funny drunks, aggressive drunks, etc. Perhaps their own personality and history is what leads them to their choices—good or bad—after a few drinks. Generally speaking, alcoholism tends to be a common (so-called) disease across the United States. However alcoholism has many shapes and molds. Alcohol can result in many different and often opposing behaviors depending on the person it is acting within.
Alcohol is commonly consumed beverage throughout the world. According to the CDC about 52% of the US population over the age of 18 are considered regular drinkers (12 or more drinks per year). Alcohol is the drink of choice for celebrations, break-ups, deaths, divorce, marriage, any event under the sun (minus a child’s birthday party). So why is it that with a beverage so common that there are addictive qualities that come along with it? Why is it that certain individuals are more prone to alcohol addiction than others? I mean, drinking is not illegal, so there must be a reason. The prohibition in the thirties didn’t work so well so the lawmakers learned better. People like alcohol and there’s nothing wrong with that. But, there’s nothing good about alcohol addiction either. So where so we draw the line?
If you or someone you know need help in an abusive situation please call the National Domestic Violence Hotline at 1-800-799-7233 (SAFE)
Or get help online at:
http://www.helpguide.org/mental/domestic_violence_abuse_help_treatment_prevention.htm
For more information about statistics of alcohol addiction please see:
http://www.cdc.gov/nchs/fastats/alcohol.htm
Alcohol as a social issue
This week’s discussions centred around ethanol and it’s many different pathways that it effects. This is relatively new research, and not much is known about how this knowledge can be used to fight issues surrounding alcohol use. For me, the biggest issues with alcohol use and abuse are societal issues. I have known many foreign exchange students from Germany and other European countries. Many of them say that the difference between the United States and other countries’ drinking practices is that because alcohol is so much a part of their society, in Europe they drink for social reasons, and in America a lot of young people drink to get drunk. This is where a lot of problems come in, when alcohol is drunken for its effects. I think that alcohol will always be a substance that is both legal and widely used because it is so engrained into our society. Knowing how alcohol takes its effects is useful from the point of view of simply “knowledge is power,” but until we can find a helpful use for this knowledge, it doesn’t help those that are using alcohol all that much. Perhaps the scientific community can develop a sort of pill that can be taken while drinking to stop the aversive effects before they start. Most people continue to drink because they like the initial feel of relaxation and disinhibition, but if we can stop the pathway of ethanol before it inhibits reasoning and decision making this would be a very beneficial use of the knowledge we have.
Brain to Fat Communication
A steamy slab of steak lies on a plate soaked in steak sauce accompanied by garlic-mashed potatoes and cheese-covered broccoli. You reach for your fork and take a bite. Little by little the massive helping of food is soon demolished. Already feeling full and a bit lethargic, you stare at a luscious piece of strawberry cheesecake. You think to yourself, “I don’t need this… I definitely shouldn’t eat it… But wait, it looks so good. I’ll just have a bite.” Before you know it, you’ve eaten the whole thing and moved onto another piece. Feeling bloated and almost sick, you sit back and relax as the lump of food sitting in your stomach begins to travel through your digestive system.
To many, this may seem like an exquisite meal. However, those that eat this excessively on a regular basis, usually combined with other unhealthy choices, commonly experience obesity. Fact is, eating like this has a huge impact on not only the digestive system but adiposity signaling as well. Adiposity signaling is communication between the brain and body fat stores in the body via the bloodstream. The way in which adiposity signaling functions has become an area of scientific interest.
For a molecule to be considered for adiposity signaling it must meet certain conditions. It must be able to secrete into the plasma relative to the fat stores, move from the brain into the bloodstream, show expression in the brain of signaling molecules that are involved with energy homeostasis, and decrease food intake. As of now, only two molecules are known to be directly associated with adiposity signaling, leptin and insulin. The effects of the molecules’ actions on neurons occur in the hypothalamus of the brain. More specifically, the region most concerned with these effects is called the hypothalamic arcuate nucleus. This area contains two neurons, proopiomelanocortin (POMC) and neuropeptide Y (NPY) with agouti related protein (AgRP), that express insulin and leptin receptors. However, POMC and NPY/AgRP have different effects depending on the levels of leptin and insulin. POMC is activated by insulin and leptin and reduces food intake and increases energy usage. NPY/AgRP also reduces food intake but is inhibited by leptin and insulin. In other words, if NPY/AgRP is secreted, food intake is stimulated.
Although the mechanism in which fat stores and the brain are connected is much more complicated than what has been explained, POMC and NPY/AgRP play an integral role. It is their existence that tells the body to eat more food or not. Even though regular exercise combined with a healthy diet should deter obesity, not everyone is able to maintain such a lifestyle. If scientists are able to engineer a drug capable of inhibiting NPY/AgRP and promoting POMC, weight loss could become more efficient.
Cheers!
What is something 52% of American adults do on a regular basis? Brush their teeth? (Just kidding…78% of adults do that). The real answer is drink alcohol. Yeah. Since drinking is such a common thing, you’d think scientists would know how alcohol affects our brains. Oddly, however, alcohol’s story in the brain is still a very complicated and confusing tale.
According to Newton and Messing in their article, “Intracellular signaling pathways that regulate behavioral responses to ethanol” Some aspects of the alcohol story are being uncovered. These effects seem to somehow involve the proteins adenylyl cyclase (AC), protein kinase A (PKA), DARPP-32, fyn kinase, protein kinase C (PKC), phospholipase D (PLD), and a fun little transcription factor called CREB.
AC, PKA, and CREB
How does ethanol signal through these molecules? It seems that ethanol decreases function of a transporter protein called ENT1. Usually ENT1 would take up adenosine, but when it’s inhibited it doesn’t – a ton of adenosine builds up outside the cell. Once this happens, there is more adenosine to activate its receptor. Since adenosine’s receptor has interactions with a Gs protein, its increased activity leads to increase AC production. Increased AC in the cell leads to cAMP production and eventually signaling via PKA. PKA signaling activates CREB which is a transcription factor and can change gene regulation! Phew. What affects does this signaling have? According to mice studies, this pathway could be important in ethanol preference and self-administration. But, it seems that effects depend on brain region.
DARPP-32 and Fyn kinase
These two proteins have some interesting and rather confusing effects on our brains. PKA pathways stimulated by dopamine signaling (which is stimulated by ethanol) activate DARPP-32 by phosphorylation. DARPP-32 then goes on to inhibit a phosphatase, PP1. PP1’s usual role is to dephosphorylate NMDA receptors to decrease brain excitability. However, when it’s inhibited, NMDA receptors remain active.
Fyn acts in a similar way. Ethanol seems to allow Fyn kinase to disassociate from its regulatory scaffolding protein, RACK. Once it gets rid of RACK it can go on to do whatever it’s feelin’……which happens to be phosphorylating NMDA receptors. And, like before, NMDA receptors are activated. It is hypothesized that this NMDA activation is important in the reward and reinforcement in ethanol consumption.
PKC
Since there are many forms of PKC acting in many brain areas, its actions can get quite complicated. Mice lacking PKCγ have decreased response to the “sleepiness/decreased brain activity” typical of alcohol and they also have decreased preference for ethanol. Mice lacking PKCε also show decreased hypnotic effects and consume less ethanol. It is thought that possibly PKC could signal through GABA receptors, glycine receptors, and voltage-gated Ca2+ channels although the facts behind this are still murky.
PLD
PLD is one molecule that can directly use ethanol as a substrate. This protein’s normal function is to hydrolyze membrane phospholipids to make phosphatidic acid (PA). PA acts as a second messenger for many things including PKC, PLC, mTOR, Raf1, phosphatidylinositol 5-kinase, and others. However, in the presence of ethanol, instead of producing PA, PLD uses ethanol to produce another molecule, phosphatidylethanol (PEth). This switch-up can produce two effects: first, you don’t make PA, and second, PEth is incorporated into cell membranes to make them more fluid. Because of these, cell signaling will be altered and neurotransmitter release may be inhibited.
It seems that alcohol has some interesting effects on our brains; however, the knowledge is certainly incomplete. Alcohol seems to have very different effects on different brain areas. In fact, some signaling molecules even have opposing effects depending on brain area. So…until we figure out more….ignorance is bliss? Drink up!
Newton, P.M., Messing, R.O. (2006) Intracellular signaling pathways that regulate behavioral responses to ethanol. Pharmacology & Therapeutics 109, 227-237.
http://crystalwineglasses78.webs.com/
Hello School, Goodbye life.
http://www.iuma.be/reverse%20punch.html
Who are we? Concussions and the like
Concussions are becoming an increasingly popular topic. The concern mainly being focused around professional athletes and the increasing literature in the dangers of suffering from multiple concussions or back-to-back concussions. This is a topic that strikes me in particular. I have suffered from multiple concussions throughout my life, a couple of which were rather severe.
After suffering from a traumatic blow to the head there is a rush of neurotransmitters into the synapses of neurons. This rush creates a large number of unchecked ionic fluctuations. This series of initial events after an impact result in some small changes in cellular physiology. The brain responds to these fluctuations by trying to restore balance. In the process of balancing, the brain experiences the hypermetabolism of glucose. This hypermetabolism of glucose is one reason why some researchers think a second concussion so early is so dangerous. The brain cannot respond adequately to a second impact, because it is already doing too much. The third stage is a depressed metabolism.
The more we know about concussions the better we can respond to one when it occurs. Unfortunately, the literature is lacking when it comes to the long term effects of suffering multiple concussions, spaced generously apart. However, many athletes have reported experiencing CTE, or chronic traumatic encephalitis, after their playing careers are over. The cognitive impairments involved in CTE are obvious and measurable. It is the subtle cognitive changes after one or a few concussions that plague the average concussion sufferer.
I hate to indulge in self-absorbed story telling in a blog, but I find this particular personal dilemma too common to not be compelling. Don’t we all wonder if something from our past or our gene pool affects us now in a profound way? I often wonder these things, and the concussions I’ve suffered from often make me wonder how different I would be if I hadn’t had them. I will reserve myself to two telling.
My first major concussion occurred when I was around three years old. I fell out of the basket of a grocery cart at my local COSCO store. I landed on my head of course. I don’t remember much of it and the story’s facts rely on my mom, who was there to witness it. To this day she gets the chills going into COSCO. I had lost consciousness that time, and often wonder how this major concussion at the age of three affected my cognitive and personal development. The second major concussion occurred when I was about 6 or 7. Me and a friend at set up a nifty “dive down the stairs onto cushions” game and were having fun. It only takes one bad jump and one misplaced cushion to make the fun go away. This is what happened. I leaped from the top of the stair case, began toppling down the cushioned stairs, and eventually slammed the back of my head at the bottom of the stairs on a cushionless area of the carpeted floor. I didn’t lose consciousness this time, but I distinctly remember seeing stars. Apparently the expression isn’t metaphorical but literal. This is it I guess. It’s interesting to wonder how these have affected us. But inevitably we can’t really know. There are just too many variables, and we really shouldn’t spend too much time worrying about it. We are who we are, regardless of what causes us.
Does this make me look fat? Treating obesity and leptin resistance
Thanksgiving: one of those holidays of the year where gluttony is encouraged. Americans make enough food to put themselves into a calorie-induced coma for days. This happens only a few times a year, though, so why not indulge once in a while?
Lately, we have been talking about weight regulation and obesity—a relevant topic indeed close to Thanksgiving! The articles we have been reading discuss leptin, a very important hormone in the brain for feeding behavior.
What is leptin?
Leptin is a hormone that is secreted from fat cells in the body. When released, leptin suppresses appetite and tells the body to stop eating. How does this regulate body weight long-term? When more fat is being stored, leptin levels will increase; leptin is telling the brain that the person should stop eating so much. This yields in a decrease of food intake and, ideally, a decrease in weight as well. Leptin is a natural regulator of weight and food intake, in this way.
Leptin produces this effect by influencing the signaling of neurons in the hypothalamus. The hypothalamus is an area in the brain that regulates hunger and feeling full. There are many signaling pathways involved in feeding behavior that are affected by leptin. Researchers are trying to target these pathways in order to find a treatment for obesity.
What about obesity?
If leptin regulates body weight, then obesity shouldn’t be the problem we see today. However, research indicates that if a person has high levels of circulating leptin (due to long-term over-eating, poor nutrition, a high-fat diet, etc.), eventually he or she can become resistant to the appetite-suppressing effect of leptin. Leptin has tried very hard to tell the brain to decrease food intake, but over time the body becomes used to it and doesn’t even listen anymore. High levels of leptin, then, cannot decrease food intake and weight because the body is resistant to it. This is why giving leptin to treat obesity doesn’t work—obese people are probably resistant to the effects of leptin already.
Treating obesity
Leptin resistance is certainly a problem. Discovery of leptin held great potential for finding a good treatment for obesity. But leptin resistance brought much of this research to a grinding halt. So how can leptin resistance (and obesity) be treated?
Well, researchers are still working on that. But there are a few ideas out there. In 2009, Harvard University researchers found two compounds that reduced leptin resistance in mice. These substances reduce inflammation in the nerves and may simply restore natural leptin functioning. It will probably be years before this treatment is available for use.
Another option that physicians are increasingly turning to in cases of extreme and difficult-to-treat obesity is gastric bypass surgery. This should be a last option after all others have been exhausted. This involves a surgery stapling a section of the stomach to form a small pouch, the “new” stomach (see diagram below). When we eat food and our stomachs fill up, the stomach walls start to stretch. Nerves in the wall sense this stretching and send messages to the brain to stop eating. This involves the signaling of a number of chemicals and hormones, including leptin. After gastric bypass surgery, the stomach fills much faster, causing a sense of fullness rapidly as well. Additionally, leptin levels are decreased (according to recent studies in 2010 and 2011). While obese people often have chronically, stubbornly high leptin levels, gastric bypass surgery may reduce leptin resistance, allowing levels to drop and normal functioning to resume.
Medication and surgery are drastic measures to treat obesity. Exercise and careful monitoring of food intake may also affect leptin and obesity. In chronic over-eating and snacking, levels of leptin rise as the brain tries to tell the body to stop eating. If a person is always eating, however, these levels will remain high all the time. Not good. Constant advertising of food, easy access to fast food, and supersized food portions may all have contributed to the high rates of obesity in America. In the 1950s, a 12-oz can of soda was considered “king size,” big enough for two servings. Now, a 12 oz. soda at McDonald’s is considered child-size, and people regularly order their 22 and 32 oz. sizes. Do we really need all those calories? The burgeoning obesity rates in our country suggest not.
Another option is good old fashioned exercise. Leptin levels increase in the brain shortly after exercise, telling the body not to eat. In people with obesity problems, long-term exercise may eventually reduce high levels of leptin. Additionally, some research has indicated that exercise can make the body more sensitive to leptin and insulin, both essential hormones for metabolism. Increased sensitivity to these hormones makes the body more efficient in using them, and resistance is reduced. Exercise is a great natural way to help restore natural leptin functioning and beat obesity.
Extra Sugar
High Fructose Corn Syrup!!!
First of all, what exactly is it? We all know that it makes an appearance in all of our food. According to the USDA, high fructose corn syrup is 3% water, 42% glucose, and 55% fructose. This particular mix is used in the soft drinks that most of us consume on a daily basis. High fructose corn syrup has replaced our table sugars as the sweetener in most of our meals. The main reason for this is because it is easier and cheaper to make. So, needless to say, since high fructose corn syrup is everywhere, do we have to worry about what it does inside our body?
Take a min to watch this SNL skit.
http://www.hulu.com/watch/223360/saturday-night-live-corn-syrup-commercial
Although humorous, the video does bring up valid points about the public being uninformed on the side effects of high fructose corn syrup, as well as the idea of moderation.
Related to the paper we just read, I found another paper that suggests that high fructose corn syrup reduces the amount of leptin and insulin in our blood stream. This is bad news for us, because leptin is what regulates our hunger, and our body’s ability to increase energy production. Without leptin, we will always be hungry. That will lead to caloric intake, and from there, to obesity!
Here is a neat graphic depicting the effects of leptin signaling from adipose tissue.
http://www.nature.com/nature/journal/v395/n6704/fig_tab/395763a0_F3.html
As you can see, increase in leptin, comes from weight gain, and this signals our body to stop eating. However, if our leptin is decreased, it will lead to hunger and caloric intake. The reason for this decrease in signaling, is that fructose doesn’t trigger the leptin signaling pathway. So, we just eat and eat and eat and nobody tells us to stop.
However, I’m still unsure on what exactly this means for our intake of high fructose corn syrup. Should I be eating it? Should I be eating only some of it? How much can really affect my body weight? These are a few questions I would like to explore further.